Carpal Tunnel Syndrome is often caused by a combination of things that all lead to pressure over the median nerve. In some instances, CTS is a result of congenital predisposition, that being the carpal tunnel is just smaller in diameter in some people. Other factors may include sustaining an injury to your wrist that results in swelling around the base of the wrist, use of vibrating hand tools or even fluid retention. However, the most common cause of Carpal Tunnel Syndrome is as a result of a repetitive strain injuries relating to computer use.